It’s possible to overdose on hydrocodone. Never take more than your prescribed dose of hydrocodone, even if you feel that the medicine is not working as well. Be sure to also tell your doctor if you’re taking any other prescription or nonprescription medications. You shouldn’t drink alcohol or take other street drugs while taking hydrocodone as these will increase your risk of experiencing serious side effects. There are also a number of factors that could alter the time it takes for hydrocodone to clear the body, including age, metabolism, weight, dose, and other medications. But the drug may still be detected in the saliva for up to 36 hours, in urine for four days, and in the hair for 90 days after the last dose. The pain relief effect of hydrocodone will wear off within four to six hours. antidepressants known as MAO inhibitors.Other medications that have been shown to interact with hydrocodone and increase its effects include: macrolide antibiotics, such as erythromycin.Drugs that inhibit CYP3A4 make it more difficult for your body to break down hydrocodone.Ĭombining hydrocodone with the following could result in serious problems, including potentially fatal respiratory depression: Hydrocodone is cleared by your body through a pathway known as cytochrome P450 3A (CYP3A). It will take longer to clear hydrocodone from your body.Ĭombining alcohol with hydrocodone can also lead to dangerous side effects, including the possibility of a fatal overdose. This means that the effects of hydrocodone are increased if you consume alcohol. how long you’ve been taking hydrocodoneĪlcohol and hydrocodone taken in combination have a synergistic effect on one another.This is why your doctor may have you take a single tablet of hydrocodone every four to six hours while you’re in pain.Įxtended-release formulations last a bit longer, so they are usually taken every 12 hours in order to control pain.įactors that influence how long the effects of hydrocodone lastĪ number of factors can influence the time it takes for hydrocodone to clear the body. You will likely stop “feeling” the pain relief of hydrocodone long before it fully clears your body. hair for up to 90 days after the last dose is taken.urine for up to four days after the last dose is taken.saliva for 12 to 36 hours after the last dose is taken.For most people, hydrocodone will fully clear the blood within a day, but it can still be detected in the saliva, urine, or hair for much longer than that.Īccording to the American Addiction Center, hydrocodone can be detected in: It takes several half-lives to fully eliminate a drug. However, it’s important to note that everyone metabolizes medications differently, so the half-life will vary from person to person. In other words, it takes 3.8 hours for the average healthy male to eliminate half of the dose of hydrocodone. Hydrocodone has an average half-life of roughly 3.8 hours in healthy adult males. The half-life is the time it takes for half of the drug to be eliminated from the body. One way to find out how long a drug will last in the body is to measure its half-life. How long does it take for the effects of hydrocodone to wear off? If you’ve been prescribed hydrocodone, you may be curious as to how long the effects will last in your body and how long the medication may show up on a drug test. Extended-release formulations of hydrocodone are specifically formulated to be difficult to crush, break, or dissolve in order to prevent abuse. For this reason, it’s classified as a federal controlled substance (C-II). Hydrocodone comes with many warnings due to its high potential for abuse and addiction. There are also several extended-release formulations of hydrocodone, including: When combined with acetaminophen or ibuprofen, hydrocodone goes by the brand names: Once in the body, hydrocodone binds to and activates the mu opiate receptor to block the feeling of pain. Hydrocodone is derived from codeine, a natural alkaloid that comes from the resin of poppy seeds. Hydrocodone may be prescribed following an injury or a major surgery or to treat other types of severe pain, like cancer pain or arthritis. It’s only used to treat people who need pain relief and who can’t be treated with other medications. Hydrocodone is an opioid drug used to relieve moderate to severe pain.
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